Trivia for Rampage
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- This will be Brad Peyton and Dwayne Johnson's 3rd film together. Previously they worked together in San Andreas (2015) and Journey 2: The Mysterious Island (2012).
- This will be Dwayne Johnson's 2nd video game movie, Doom (2005) was his first.
- Jeffrey Dean Morgan and Malin Ackerman previously starred together in Watchmen (2009).
- This is Brad Peyton and Breanne Hill's first collaboration since San Andreas (2015) and Frontier (2016).
- This is Marley Shelton and Malin Akerman first collaboration since Elektra Luxx (2010).
- Both Dwayne Johnson and P.J. Byrne starred in a movie entitled "snitch." P. J.'s movie came out in 2011 and Dwayne's movie came out in 2013.
- This is Jeffrey Dean Morgan and Matt Gerald's first collaboration since Solace (2015).
- Both Joe Manganiello and Malin Akerman starred in How I Met Your Mother (2005).
- This is Brad Peyton's first video game movie, he is directing Just Cause next.
- Both Dwayne Johnson and Jeffrey Dean Morgan were in a Star Trek series. Johnson was The Champion in Star Trek: Voyager (1995) and Morgan was Xindi-Reptilian in Star Trek: Enterprise (2001).
- Both Dwayne Johnson and P. J. Bryne starred in Hannah Montana (2006).
- In the games, Lizzie was a human like George and Ralph used to be. She mutated into a giant lizard through experiments from Scumlabs. However, in this adaptation, Lizzie was always a normal crocodile until she mutated into a large beast.
- Both Dwayne Johnson and Joe Manganiello worked with Arnold Schwarzenegger. Johnson was in The Rundown (2003), which had a Schwarzenegger cameo; and Schwarzenegger and Manganiello starred in Sabotage (2014).
- Fourth film to feature Dwayne Johnson and Matt Gerald. Both also appeared together in G.I. Joe: Retaliation, Faster, and San Andreas.
- Dwayne Johnson, Jeffrey Dean Morgan and Joe Manganiello are all part of the DCEU.